How Does DNA Influence My Nutrient Needs?

Nutrigenetics is the interaction between your genes and the nutrients you consume.

It explains why “one-size-fits-all” health products do not work.

In other words, your genetic profile (i.e. your DNA) influences the metabolism of vitamins and minerals found in food. The goal of nutrigenetics is to determine how your genetic makeup influences your unique nutrient requirements.

Nutrigenetics is the foundation of truly personalized health products. Compared to the population average, you may require more of a nutrient, less of a nutrient, a certain form of a nutrient, or to avoid a nutrient entirely.

Nutrigenetics Tells You

nutrients you need more of

nutrients you need less of

best nutrient forms for you

nutrients to avoid completely

The Best Data? DNA vs. Blood vs. Lifestyle

We compile your DNA data, blood nutrient levels, and lifestyle factors to create a complete picture of your nutrient needs.

Most other “custom vitamin” brands base their recommendations solely on lifestyle quizzes (data about height, weight, diet, and other factors). While lifestyle quizzes show the nutrients you may need based on your habits, they entirely lack information about what is occurring in your body at a molecular level, and can be misleading without context provided by DNA and Blood data.

For example, a lifestyle quiz may show adequate folate intake due to a diet rich in fruits and vegetables but the person may have a common MTHFR mutation that makes it difficult to convert this folate into its bioactive form, and may need additional folic acid (or bioactive folate) compared to the norm. See below for more info.

"Rootine's at-home DNA Test analyzes 52 genetic variants that have a proven impact on nutrient needs."

— Daniel Wallerstorfer PhD Biotechnology

Let’s See Examples:

MTHFR and Folate (Folic Acid)

Folate (also commonly called folic acid) is vitamin B9. Approximately 85% of people have a mutation in their MTHFR gene. This slows the conversion of folate into its active form, called bioactive folate (methylfolate or 5-MTHF).

Marginally slower MTHFR enzymes can be corrected with a simple increase in folic acid. Severely impacted MTHFR enzymes should be bypassed entirely via direct 5-MTHF supplementation.

VDR and Vitamin D

Vitamin D is a hormone-like vitamin produced when direct sunlight hits the skin, and can also be absorbed from certain foods (e.g. fatty fish).

Vitamin D is recognized with the Vitamin D Receptor, or “VDR” for short. Approximately 11% of people have a mutation in their VDR gene, which means they need more vitamin D compared to the norm.

LCT and Calcium (Ca)

Calcium in modern diets often comes from dairy products. Approximately 9% of the population has a mutation in the LCT gene that makes them unable to digest lactose, resulting in lactose intolerance.

Studies show that people with the LCT mutation tend to avoid dairy and therefore consume about 200mg less calcium per day, compared to the average.

HFE and Iron

Iron is an essential mineral and is used to transport oxygen through the body on red blood cells. But too much iron can be very harmful.

Hemochromatosis is a rare, but often preventable condition, where excess iron slowly builds up in the body and can lead to cancer and cirrhosis of the liver. For people with genetic hemochromatosis, even small amounts of iron in a supplement can be quite harmful.

NQO1 and CoenzymeQ10

Coenzyme Q10, also known as CoQ10, is a mitochondrial antioxidant that is part of the “cellular respiration” process. The NQO1 enzyme is responsible for converting CoQ10 into the active form.

Approximately 4% of the population has a mutation in both NQO1 genes which prevents CoQ10 from being activated. An additional ~30% of the population has a mutation in one NQO1 gene, resulting in significantly slowed activation.

GPX1 and Selenium

Your body produces its own master antioxidant called the “Glutathione peroxidase 1 enzyme,” or GPX1 for short.

Approximately 38% of the population has a mutation in the GPX1 gene that reduces the enzymes antioxidant capacity, and need additional selenium to achieve the same level of GPX1 enzyme efficiency.

APOA1 and Omega-3

Omega-3 supplements are widely used to improve HDL cholesterol and reduce blood triglycerides.

However, a variant in the APOA1 gene can change this narrative. One version of the APOA1 gene makes additional omega-3 intake lower HDL levels.This version of APOA1 is found in approximately 66% of the population.